Septicemia caused by Gram-negative bacteria is an infection associated with liver dysfunction.Quercetin is a natural flavonoid found in vegetables and fruits and has anti-inflammatory, antioxidant, cytoprotective and antiallergic properties.This research aims to investigate the effects of quercetin on the liver against tissue damage due to sepsis-induced oxidative stress.Thirty-two male rats were used in the study.The animals HAIR CARE were randomly divided into 5 groups.
Quercetin was dissolved in 20 mg/kg of olive oil daily for 15 days and given through oral gavage.The cecal-ligation sepsis model was applied to the group 3 and group 4.In histopathological evaluation; inflammation involving moderate neutrophils and lymphocytes was observed in most portal areas in the group where sepsis was created (Group 3).In the sepsis group administered quercetin (Group 4) only a few portal areas had a milder inflammation with fewer neutrophils than the sepsis group.There was a significant difference between group 3, 4, and all other groups in ALT and AST values.
A significant difference was observed between group 3, 4 and other groups in terms of tissue MDA, GSH levels.It was concluded that quercetin, a powerful antioxidant, can reduce liver Clear Cases damage caused by sepsis and has the potential to be used to help treat sepsis.